WHO ARE WE?
Prof. Dr. Canfeza Sezgin, Medical Oncologist & Internal Medicine Specialist & Phytotherapist
The Chief of Canfeza Sezgin Medical & Complementary Cancer Therapy Clinic
Istanbul, Turkey
CEO, Canfeza Sezgin Farma Phytotherapy Ltd Company, Istanbul, Turkey
He graduated from Ege University Faculty of Medicine in 1993. He became Internal Medicine Specialist in 1999, Medical Oncology Specialist in 2001, Associate Professor of Medical Oncology in 2006 and Medical Oncology Professor in 2013. In March 2016, he led the establishment of the Medical Oncology Clinic at Biruni University Faculty of Medicine Hospital. Today, he continues his academic studies as a faculty member at Istinye University Faculty of Medicine (Istanbul, Turkey).
In addition to medical treatment of cancer, complementary therapies are applied together with integrative treatments. He continues his professional life in Istanbul, Turkey.
His research focuses on in vitro cancer cell lines, and has been published in more than a hundred international and national journals on various topics.
He completed his phytotherapy training in 2006 and 2016 and his hypnosis training in 2007 due to his special interest in the field of Complementary Medicine in cancer.
In 2016, he received the Complementary Hyperthermia Therapy training in cancer in Germany. He completed Ozone Practice Training in 2017.
He has been doing scientific studies related to herbal products. The Turmeric Black Pepper Cinnamon Liquid Extract, which was developed as a result of 5 years of research at Izmir Institute of Technology, and it has received the Technological Product certificate. He also patented the nanotechnological double layer Curcumin / Piperin product. He has published 2 in vitro scientific articles with this product together with the his research team. He is still conducting animal studies with his colleagues.
His book the name of ‘Which Plant Which Cancer?’ was published in 2010. His book, ‘There Is Solution To Cancer’ co-authored with 13 scientists, was published in 2011. He was the Special Issue Editor of The Journal of Complementary Supportive Therapies in Oncology in 2012.
In 2016, he published his book entitled ‘The Full Healing’ (952 pages and more than 2000 scientific references). In the book named ‘The Full Healing’, life & nutrition changes, medical treatments and herbal prescriptions are included in the fight against diseases.
In March 2019, he will published his book entitled ‘Cancer Myths and Facts’. In the his book, the cases reports will be presented related with deep tissue RF hyperthermia therapy, phytotherapy and insulin potentiated chemotherapy.
The importance of the immune system in the Covid pandemic, which affects the whole world, is better understood. With the onset of the pandemic, the book 'Super Immunity with Super Foods', which describes natural treatments that will strengthen people's immune system, was published in July 2020.
His book, 'The Power of Plants in Cancer Treatment', written in the light of current scientific literature, was published in November 2022. The book explains the use of phytotherapy in cancer treatment with scientific evidence.
He is on the Scientific Advisory Board for the Traditional and Complementary Medical Practices of the Turkey Ministry of Health. He is the founding president of the Phytotherapy Association, which was founded in 2017.
He is a member of the European Society for Medical Oncology. He is also a member of the International Clinical Hyperthermia Society (ICHS) Board, which provides scientific training for hyperthermia.
Professional organizations of which he is a member:
European Society for Medical Oncology (ESMO)
Lung Cancer Society
Medical Oncology Association
Turkish Oncology Group
Izmir Breast Association
Energy Medicine and Practices Association
Society of Clinical and Applied Hypnosis
Phytotherapy Association
European Association of Hyperthermia
Scientific research published in international peer-reviewed journals:
A1. Sanli UA, Uslu R, Sezgin C, Karabulut B, Goker E, “Docetaxel: A First Choice in the Management of Anthracycline-Resistant Metastatic Breast Cancer” Journal of B.U.O.N, 5, 399-403, (2000).
A2. Uslu R, Sanli UA, Sezgin C, Karabulut B, Terzioglu E, Omay SB, Goker E, “Arsenic trioxide-mediated cytotoxicity and apoptosis in prostate and ovarian carcinoma cell lines”, Clin Cancer Res, 6(12),4957-64, (2000).
A3. Sanli UA, Uslu R, Karabulut B, Sezgin C, Saydam G, Omay SB, Goker E, “Which dosing scheme is suitable for the taxanes? An in vitro model”, Arch Pharm Res, 25(4), 550-555, (2002).
A4. Sanal SM, Gokmen E, Karabulut B, Sezgin C, “Gemcitabine and vinorelbine combination in patients with metastatic breast cancer”, Breast J, 8(3),171-176, (2002).
A5. Sanli UA, Uslu R, Karabulut B, Sezgin C, Selvi N, Aydin HH, Saydam G, Goker E, Omay SB, “Alterations in the activity and expression of serine/ threonine protein phosphatases during atra-induced apoptosis of breast cancer cells”, Oncol Rep, 10(6), 2083-2088, (2003).
A6. Oktem G, Karabulut B, Selvi N, Sezgin C, Sanli UA, Uslu R, Yurtseven ME, Omay SB, “Differential Effects of Doxorubicin and Docetaxel on Nitric Oxide Production and Inducible Nitric Oxide Synthase Expression in MCF-7 Human Breast Cancer Cells”, Oncol Res, 14(7-8),381-386, (2004).
A7. Karasulu HY, Karabulut B, Kantarci G, Ozguney I, Sezgin C, Sanli UA, Goker E, “Preparation of arsenic trioxide loaded microemulsion and its enhanced cytotoxicity on MCF-7 breast cancer cell line”, Drug Deliv, 11(6),345-350, (2004).
A8. Ruchan Uslu, Ulus Ali Sanli, Yilmaz Dikmen, Bulent Karabulut, Aydin Ozsaran, Canfeza Sezgin, Gamze Goksel Muezzinoglu, Serdar Bedii Omay, Erdem Goker, “Predictive Value of Serum IL-8 Levels in Ovarian Cancer Patients Treated With Paclitaxel-Containing Regimens” Int J Gynecol Cancer, 15,240-245, (2005).
A9. Sezgin C, Karabulut B, Uslu R, Sanli UA, Goksel G, Zekioglu O, Ozdemir N, Goker E, “Potential predictive factors for response to weekly paclitaxel treatment in patients with metastatic breast cancer”, J Chemother,17(1):96-103. (2005).
A10. Kurt E, Sezgin C, Evrensel T, Yalçınkaya U, Kanat O, Veral A, Demiray M, Arslan M, Karabulut B, Ercan I, Goker E, Manavoglu O, “Therapy, outcome and analysis of c-kit expression in patients with extrapulmonary small cell carcinoma”, Int J Clin Pract, 59(5), 537-543, (2005).
A11. Sezgin C, Karabulut B, Uslu R, Sanli UA, Goksel G, Yuzer Y, Goker E. Gemcitabine Treatment in Patients with Inoperable Locally Advanced/Metastatic Pancreatic Cancer and Prognostic Factors. Scand J Gastroenterol. 2005 Dec;40(12):1486-92.
A12. Bulent Karabulut, Canfeza Sezgin, Cosan M. Terek, Ruchan Uslu, Ulus Ali Sanli, Levent Akman, Aydin Özsaran, Yilmaz Dikmen, Erdem Göker. Topotecan in Platinum-Resistant Epithelial Ovarian Cancer. Chemotherapy 2005;51:347-351.
A13. Canfeza Sezgin, Ender Kurt, Turkan Evrensel, Necmettin Ozdemir, Osman Manavoglu, Erdem Goker. Efficacy of lower dose capecitabine in patients with metastatic breast cancer and factors influencing therapeutic response and outcome. South Med J 2007;100(1):27-32.
A14. Canfeza Sezgin, Erhan Gokmen, Mustafa Esassolak, Necmettin Ozdemir, Erdem Goker. Risk Factors for Central Nervous System Metastasis in Patients with Metastatic Breast Cancer. Medical Oncology 2007;24(2):155-161.
A15. Saydam BK, Goksel G, Korkmaz E, Kapkac M, Ozdemir N, Sezgin C, Uslu R. Comparison of the clinical and pathological features between patients with recurrent metastatic breast carcinoma and patients with initially metastatic breast carcinoma. Saudi Med J 2008;29(1):81-6.
A16. Saydam BK, Goksel G, Korkmaz E, Zekioglu O, Kapkac M, Sanli UA, Uslu R, Sezgin C. Comparison of Inflammatory Breast Cancer and Non-Inflammatory Breast Cancer in Western Turkey. Medical Principles and Practice 2008, 018.
A17. Varol U, Karaca B, Tunali D, Degirmenci M, Cirak Y, Purcu DU, Uzunoglu S, Sezgin C, Karabulut B, Sanli UA, Uslu R. The effect of racemic gossypol and at-101 on angiogenic profile of ovcar-3 cells: a preliminary molecular framework for gossypol enantiomers. Exp Oncol 2009;31(4):220-5.
A18. Karabulut B, Karaca B, Atmaca H, Kisim A, Uzunoglu S, Sezgin C, Uslu R. Regulation of apoptosis-related molecules by synergistic combination of all-trans retinoic acid and zoledronic acid in hormone-refractory prostate cancer cell lines. Mol Biol Rep 2010 Mar 28 [Epub ahead of print].
A19. Sahin F, Avci CB, Gunduz C, Sezgin C, Simsir IY, Saydam G. Gossypol exerts its cytotoxic effect on HL-60 leukemic cell line via decreasing activity of protein phosphatase 2A and interacting with human telomerase reverse transcriptase activity. Hematology 2010;15(3):144-50.
A20. Uzunoglu S, Karaca B, Atmaca H, Kisim A, Sezgin C, Karabulut B, Uslu R. Comparison of XTT and Alamar blue assays in the assessment of the viability of various human cancer cell lines by AT-101 (-/- gossypol). Toxicol Mech Methods 2010;20(8):482-6.
A21. Sezgin C, Gokmen E, Kapkac M, Zekioglu O, Esassolak M, Karabulut B, Sanli UA, Uslu R. p53 protein accumulation and presence of visceral metastasis are independent prognostic factors for survival in patients with metastatic inflammatory breast carcinoma. Med Princ Pract 2011;20:159-164.
A22. Kisim A, Atmaca H, Cakar B, Karabulut B, Sezgin C, Uzunoglu S, Uslu R, Karaca B. Pretreatment with AT-101 enhances tumor necrosis factor-related apoptosis-indusing ligand (TRAIL)- induced apoptosis of breast cancer cells by inducing death receptors 4 and 5 protein levels. J Cancer Res Clin Oncol; published online: 13 Mar 2012.
A23. Cirak Y, Varol U, Atmaca H, Kisim A, Sezgin C, Karabulut B, Uzunoglu S, Uslu R, Karaca B. Zoledronic acid in combination with serine/threonine phosphatase inhibitors induces enhanced cytotoxicity and apoptosis in hormone-refractory prostate cancer cell lines by decreasing the activities of PP1 and PP2A. BJU Int. 2012 Aug 9. doi: 10.1111/j.1464-410X.2012.11392.x. [Epub ahead of print].
A24. Varol U, Karaca B, Cakar B, Sezgin C, Karabulut B, Uslu R. Comparing Time to Disease Progression of Irinotecan and Oxaliplatin-based Chemotherapies in Colorectal Cancer Patients With Liver Only Metastasis. Am J Clin Oncol. 2012 May 24. [Epub ahead of print]
A25. Varol Y, Varol U, Karaca B, Karabulut B, Sezgin C, Uslu R. The frequency and significance of radiologically detected indeterminate pulmonary nodules in patients with colorectal cancer. Med Princ Pract. 2012;21(5):457-61. Epub 2012 Apr 27.
A26. Içli F, Altundağ K, Akbulut H, Paydaş S, Başaran G, Saip P, Doğu GG, Eralp Y, Uslu R, Sevinç A, Onur H, Mandel NM, Sezgin C, Altınbaş M, Güler N, Işıkdoğan A, Gökmen E, Uygun K, Ustüner Z, Yaren A, Demirkan B, Coşkun U, Ata A, Ozkan M, Arican A. Nine weeks versus 1 year adjuvant trastuzumab in patients with early breast cancer: an observational study by the Turkish Oncology Group (TOG). Breast Cancer. 2013 Dec 12. [Epub ahead of print]
A27. Varol U, Cirak Y, Cakar B, Karaca B, Sezgin C, Uslu R, Karabulut B. Survival analysis of metastatic colorectal cancer patients who were treated with the five major therapeutic agents over the course of disease. J BUON. 2013 Jul-Sep;18(3):647-52.
A28. Cakar B, Varol U, Junushova B, Muslu U, Gursoy Oner P, Gokhan Surmeli Z, Cirak Y, Karaca B, Sezgin C, Karabulut B, Uslu R. Evaluation of the efficacy of adjuvant chemotherapy in patients with high-risk stage II colon cancer. J BUON. 2013 Apr-Jun;18(2):372-6.
A29. Karaca B, Atmaca H, Bozkurt E, Kisim A, Uzunoglu S, Karabulut B, Sezgin C, Sanli UA, Uslu R. Combination of AT-101/cisplatin overcomes chemoresistance by inducing apoptosis and modulating epigenetics in human ovarian cancer cells. Mol Biol Rep. 2013 Jun;40(6):3925-33. doi: 10.1007/s11033-012-2469-z. Epub 2012 Dec
A30. Varol U, Karaca B, Cakar B, Sezgin C, Karabulut B, Uslu R.Comparing time to disease progression of irinotecan and oxaliplatin-based chemotherapies in colorectal cancer patients with liver only metastasis. Am J Clin Oncol. 2013 Aug;36(4):388-91.
A31. Varol U, Degirmenci M, Karaca B, Atmaca H, Kisim A, Uzunoglu S, Sezgin C, Sanli UA, Uslu R. Zoledronic acid increases cytotoxicity by inducing apoptosis in hormone and docetaxel-resistant prostate cancer cell lines. Tumour Biol. 2014 Oct 9. [Epub ahead of print].
A32. Genç M, Genç B, Solak A, Gür E, Sezgin C. Bilateral Krukenberg tumor in a 16-week pregnant woman. Eur J Gynaecol Oncol. 2014;35(1):95-6.
A33. Cakar B, Muslu U, Erdogan AP, Ozisik M, Ozisik H, Tunakan Dalgic C, Durusoy R, Karaca B, Sezgin C, Karabulut B, Uslu R. The Role of Body Mass Index in Triple Negative Breast Cancer. Oncol Res Treat. 2015;38(10):518-22.
A34. Surmeli Z, Gursoy P, Erdogan AP, Bozkurt E, Atmaca H, Uzunoglu S, Sezgin C, Şanlı UA, Uslu R, Karaca B. Combination of zoledronic acid and serine/threonine phosphatase inhibitors induces synergistic cytotoxicity and apoptosis in human breast cancer cells via inhibition of PI3K/Akt pathway. Tumour Biol. 2016 Mar;37(3):3665-73.
A35. Baspinar Y, Üstündas M, Bayraktar O, Sezgin C. Curcumin and piperine loaded zein-chitosan nanoparticles: Development and in-vitro characterisation. Saudi Pharm J. 2018 Mar;26(3):323-334.
A36. Canbay E, Canbay Torun B, Cosarcan K, Altunal C, Gurbuz B, Bilgic C, Sezgin C, Kaban KK, Yilmaz S, Yazici Z. Surgery with hyperthermic intraperitoneal chemotherapy after response to induction chemotherapy in patients with peritoneal metastasis of gastric cancer. J Gastrointest Oncol. 2021 Apr;12(Suppl 1):S47-S56.
