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Ozone Therapy

Ozone gas is a molecule of three-atom oxygen and its formula is O3. It has a distinct sharp and pungent smell. It is one of the most powerful oxidizing agents and has a 99.9% killing effect against bacteria, fungi, and viruses. Ozone has specific effects within certain dosage ranges. It is safe when applied with standardized, properly designed devices and methods.
Ozone therapy has been shown to have beneficial effects for a wide range of health conditions, including:

  • Reducing the side effects of radiation and chemotherapy
  • Supporting brain circulation and limiting stroke in the first 48 hours
  • Supporting the immune system in cancer patients
  • Increasing the oxygenation of cancerous tumors to enhance the response to cancer treatment
  • Treatment of cancer-related jaw osteonecrosis
  • Boosting the immune system and increasing physical energy
  • Delaying skin aging and promoting a youthful, smooth appearance
  • General detoxification
  • Treatment of infections (viral illnesses such as flu, colds, AIDS, SARS, bacterial infections)
  • Age-related macular degeneration treatment
  • Reducing stress and promoting sleep balance.
  • Correcting circulatory disorders
  • Treatment of rheumatic diseases, osteoarthritis, inflammatory joint rheumatism
  • Treatment of non-healing wounds caused by surgery or infection
  • Correction of chronic fatigue syndrome and resolution of muscle-skeletal pain
  • Supporting liver and kidney function in cases of organ failure
  • Improving diabetes and diabetic complications
  • Treatment of ulcerative colitis and Crohn's disease
  • Treatment of wounds and burns

Reference:
1. Saad Zaky, Ehab Ahmad Fouad, Hassan Ibrahim Mohamad Kotb. The effect of rectal ozone on the portal vein oxygenation and pharmacokinetics of propranolol in liver cirrhosis (a preliminary human study). Br J Clin Pharmacol. 2011 Mar; 71(3): 411–415.
2. Ricardo González, Aluet Borrego, Zullyt Zamora. Reversion by ozone treatment of acute nephrotoxicity induced by cisplatin in rats. Mediators Inflamm. 2004 Dec; 13(5-6): 307–312.
3. https://www.medicalnewstoday.com/articles/320759.php
4. Wainstein J, Feldbrin Z, Boaz M, Harman-Boehm I. Efficacy of ozone-oxygen therapy for the treatment of diabetic foot ulcers. Diabetes Technol Ther. 2011 Dec;13(12):1255-60.
5. Shah P, Shyam AK, Shah S. Adjuvant combined ozone therapy for extensive wound over tibia. Indian Journal of Orthopaedics. 2011;45(4):376-379.
6. Vasanthi R. Sunil, Kinal Patel-Vayas, Jianliang Shen. Classical and Alternative Macrophage Activation in the Lung following Ozone-induced Oxidative Stress. Toxicol Appl Pharmacol. 2012 Sep 1; 263(2): 195–202.
7. Feng X, Beiping L. Therapeutic Efficacy of Ozone Injection into the Knee for the Osteoarthritis Patient along with Oral Celecoxib and Glucosamine. Journal of Clinical and Diagnostic Research : JCDR. 2017;11(9):UC01-UC03.
8. Geng Y, Wang W, Ma Q, Peng LQ, Liang ZH. [Ozone therapy combined with sulfasalazine delivered via a colon therapy system for treatment of ulcerative colitis]. Nan Fang Yi Ke Da Xue Xue Bao. 2010 Dec;30(12):2683-5.
9. Clavo B, Catalá L, Pérez JL, Rodríguez V, Robaina F. Ozone Therapy on Cerebral Blood Flow: A Preliminary Report. Evidence-based Complementary and Alternative Medicine. 2004;1(3):315-319.
10. Wasser G. Ischemic Stroke Penumbra and Extracorporeal Ozone Treatment. The Neuroradiology Journal. 2013;26(3):243-251.
11. Clavo B, Pérez JL, López L, et al. Ozone Therapy for Tumor Oxygenation: a Pilot Study. Evidence-based Complementary and Alternative Medicine. 2004;1(1):93-98.
12. Kohei Kuroda, Kazuo Azuma, Takuro Mori. The Safety and Anti-Tumor Effects of Ozonated Water in Vivo. Int J Mol Sci. 2015 Oct; 16(10): 25108–25120.
13. Noel L. Smith, Anthony L. Wilson, Jason Gandhi. Ozone therapy: an overview of pharmacodynamics, current research, and clinical utility. Med Gas Res. 2017; 7(3): 212–219.
14. Bernardino Clavo, Ana Ruiz, Marta Lloret. Adjuvant Ozonetherapy in Advanced Head and Neck Tumors: A Comparative Study. Evid Based Complement Alternat Med. 2004 Dec; 1(3): 321–325.
15. Bernardino Clavo, Norberto Santana-Rodriguez, Pedro Llontop. Ozone Therapy in the Management of Persistent Radiation-Induced Rectal Bleeding in Prostate Cancer Patients. Evid Based Complement Alternat Med. 2015; 2015: 480369.
16. C.I. Ripamonti, M. Maniezzo, S. Boldini. Efficacy and tolerability of medical ozone gas insufflations in patients with osteonecrosis of the jaw treated with bisphosphonates—Preliminary data. J Bone Oncol. 2012 Dec; 1(3): 81–87.




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